To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. For general information, see Devalia JL, De Vos C, Hanotte F, Baltes E. In a recent paper from Japan it was observed that the improvement rates (defined as a urticaria symptom score UAS ≤ 3) in 117 CU patients who received standard doses of AHs were 36.6% at 12 months, 51.2% at 24 months, and 66.1% at 60 months, while the remission rates were 11.5%, 13.9%, and 27.7%, respectively .
They reported that out of 390 CU patients who were treated with antihistamines 44% responded well, 29% became asymptomatic, and 15% showed partial improvement.CSU has been defined as wheals and/or angioedema that are endogenous and independent of any external physical stimulus. In 40 to 45% of patients with CSU autoantibodies to the high affinity Ig E receptor (FcϵRI) or to Ig E itself are thought to play a psathogenic role, whereas 55 to 60% of cases are considered idiopathic .Inducible urticarias include all forms of physical urticarias (cold-induced, heat-induced, solar, and pressure urticaria).Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug).In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death.